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The Newest Darlings of the Super Aging Community

"If I'm ninety and believe I'm forty-five, I'm headed for a very bad time trying to get out of the bathtub." Ursula Le Guin on the absurdity of denying your age. d. 1/2018 at 89.

The first darlings I will discuss are called Senolytics, and they act like garbage trucks for the body. I am very excited about these. Old, tired cells  called senescent cells - can pile up in aging bodies, instead of being destroyed as they are in younger more vital bodies. They then start crowding out the new cells trying to replace them and furthermore these cranky old cells  nasty little buggers - seem to infect the existing new cells with toxic enzymes rendering them weak and ineffective.

And what does this do? This non-clearance of old cells creates inflammation and shortened telomeres; they inflict damage on stem cells, damage cellular DNA and mitochondria; and the old cells create excess tau proteins and neurofibrillary tangles in the hippocampus which then leads to dementia.

Researchers noticed this and realized the importance of removing the old cells. They discovered that a combination of a chemotherapeutic drug and quercetin could remove the senescent cells. Now, you and I don't want to do the dasatinib (chemo) and we need a special kind of bioavailable quercetin which the Life Extension scientists have developed in a very handy, very inexpensive capsule called Senolytic Activator. What they did is this: They combined this special bio-quercetin phytosome with theaflavins from black tea, which purportedly acts like the chemo drug, dasatinib.

The conventional medical journals are all over this: JAMA: "In animal models, both health and longevity have been extended." JAMA again: "Targeting senescent cells may arrest or reverse Alzheimer's and related neurodegenerative diseases." Aging Cell: "Improves health span and delays age-associated diseases." Mayo Clinic: Senolytics could transform care of older adults and patients with multiple chronic diseases..."

I signed up as soon as it was available. And, here's the good part. You take just 2 pills once a week and the box of 24 pills (labelled day one, day two, day three and so forth) is just $24! So, why only 2 pills? Because the Life Extension scientists discovered that if you take any more than 2 pills per week, it starts to degrade the new, good, youthful cells, too. I take my 2 pills every Monday without fail and I have the Senolytic Activator on my shelves now.

Here are some interesting and useful formulas for you: 1) .36 times your body weight is the amount of protein you should eat in a day. No more, please. 2) 180 minus your age equals the pulse rate at which oxygen is being put through your body to fuel fat burning, or your maximum aerobic function. 3) 7,000 to 9,000 steps per day is fine for those of us over 65. Leave the 10,000 + steps to the younguns'.

The second new infatuation for the anti-aging community is AMPK Activation or Your Body's "Youth Switch": AMPK is a lovely cousin to the Senolytics as it is one of the most powerful antiaging tools. It is an enzyme which promotes regenerative pathways and acts in every cell to restore youthful function.( I'm going to tell you what the acronym stands for, but I don't expect you to remember it, any more than I can: Adenosine monophosphate-activated protein kinase.)

Here are all the things that you can enjoy by activating your AMPK: Reduce risk of atherosclerosis, heart attack and stroke, ameliorate metabolic syndrome, reduce risk of weight gain, decrease risk of several cancers, reduce risk of dementia, support healthy bone and cartilage structure, help prevent and control autoimmune disorders. And on a noticeable and practical level, it can magically reduce abdominal fat which is all too prevalent in the aging population. (A patient called me, ecstatic, and said that "I'm losing my tummy!" She had been taking AMPK for one week.) I have AMPK on my shelves ready to go.

How to live to at least 90. If you are taking CoQ10 and if you are over 50 you should be taking 100 mgs. per day. But now start adding at least 50mgs of selenium when you take your Q10. Take them together, in the morning. Research for 5.2 years with 443 men and women average age 78 who received either placebo or Q10 plus selenium revealed that the Q10/selenium group had less than ½ the risk of CV mortality than the placebo group. After 12 years, 45% of the Q10 plus selenium group was still alive vs. 28.1% of the placebo group. PLOS, 4/11/18.

The bright side of anti-depressants: Researchers found that SSRI's like Zoloft, Prozac and Paxil inhibited the growth of amyloid plaques in the brain by 74-76%, thus reducing the risk of dementia in these people. Univ. of Waterloo. Ontario, Canada in Medical New Today 10/17/18
No, I am not advocating this treatment.

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